Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials

BACKGROUND: The MAPK-interacting kinase 1 (MKNK1) is localized downstream of the RAS/RAF/ERK and the MAP3K1/MKK/p38 signaling pathway. Through phosphorylation MKNK1 regulates the function of eukaryotic translation initiation factor 4E, a key player in translational control, whose expression is often...

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Bibliografiske detaljer
Udgivet i:Ann Oncol
Main Authors: Berger, M D, Stintzing, S, Heinemann, V, Yang, D, Cao, S, Sunakawa, Y, Ning, Y, Matsusaka, S, Okazaki, S, Miyamoto, Y, Suenaga, M, Schirripa, M, Soni, S, Zhang, W, Falcone, A, Loupakis, F, Lenz, H -J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834083/
https://ncbi.nlm.nih.gov/pubmed/29045529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdx412
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