Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials

PURPOSE: The most frequent bevacizumab-related side-effects are hypertension, proteinuria, bleeding and thromboembolism. To date, there is no biomarker that predicts anti-VEGF–associated toxicity. As autophagy inhibits angiogenesis, we hypothesised that single-nucleotide polymorphisms (SNPs) within...

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Udgivet i:Eur J Cancer
Main Authors: Berger, Martin D., Yamauchi, Shinichi, Cao, Shu, Hanna, Diana L., Sunakawa, Yu, Schirripa, Marta, Matsusaka, Satoshi, Yang, Dongyun, Groshen, Susan, Zhang, Wu, Ning, Yan, Okazaki, Satoshi, Miyamoto, Yuji, Suenaga, Mitsukuni, Lonardi, Sara, Cremolini, Chiara, Falcone, Alfredo, Heinemann, Volker, Loupakis, Fotios, Stintzing, Sebastian, Lenz, Heinz-Josef
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497847/
https://ncbi.nlm.nih.gov/pubmed/28347919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2017.02.020
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