Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials

PURPOSE: The most frequent bevacizumab-related side-effects are hypertension, proteinuria, bleeding and thromboembolism. To date, there is no biomarker that predicts anti-VEGF–associated toxicity. As autophagy inhibits angiogenesis, we hypothesised that single-nucleotide polymorphisms (SNPs) within...

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Veröffentlicht in:Eur J Cancer
Hauptverfasser: Berger, Martin D., Yamauchi, Shinichi, Cao, Shu, Hanna, Diana L., Sunakawa, Yu, Schirripa, Marta, Matsusaka, Satoshi, Yang, Dongyun, Groshen, Susan, Zhang, Wu, Ning, Yan, Okazaki, Satoshi, Miyamoto, Yuji, Suenaga, Mitsukuni, Lonardi, Sara, Cremolini, Chiara, Falcone, Alfredo, Heinemann, Volker, Loupakis, Fotios, Stintzing, Sebastian, Lenz, Heinz-Josef
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497847/
https://ncbi.nlm.nih.gov/pubmed/28347919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2017.02.020
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