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A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: Data from FIRE-3 and TRIBE trials
BACKGROUND: Through enhancement of the Wnt signaling pathway R-spondins are oncogenic drivers in colorectal cancer. Experimental data suggest that the R-spondin/Wnt axis stimulates VEGF-dependent angiogenesis. We therefore hypothesize that variations within R-spondin genes predict outcome in patient...
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| 發表在: | Eur J Cancer |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7513926/ https://ncbi.nlm.nih.gov/pubmed/32305727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2020.02.048 |
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