A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: Data from FIRE-3 and TRIBE trials

BACKGROUND: Through enhancement of the Wnt signaling pathway R-spondins are oncogenic drivers in colorectal cancer. Experimental data suggest that the R-spondin/Wnt axis stimulates VEGF-dependent angiogenesis. We therefore hypothesize that variations within R-spondin genes predict outcome in patient...

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書誌詳細
出版年:Eur J Cancer
主要な著者: Berger, Martin D., Ning, Yan, Stintzing, Sebastian, Heinemann, Volker, Cao, Shu, Zhang, Wu, Yang, Dongyun, Miyamoto, Yuji, Suenaga, Mitsukuni, Schirripa, Marta, Hanna, Diana L., Soni, Shivani, Puccini, Alberto, Tokunaga, Ryuma, Naseem, Madiha, Battaglin, Francesca, Cremolini, Chiara, Falcone, Alfredo, Loupakis, Fotios, Lenz, Heinz-Josef
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513926/
https://ncbi.nlm.nih.gov/pubmed/32305727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2020.02.048
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