A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: Data from FIRE-3 and TRIBE trials

BACKGROUND: Through enhancement of the Wnt signaling pathway R-spondins are oncogenic drivers in colorectal cancer. Experimental data suggest that the R-spondin/Wnt axis stimulates VEGF-dependent angiogenesis. We therefore hypothesize that variations within R-spondin genes predict outcome in patient...

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發表在:Eur J Cancer
Main Authors: Berger, Martin D., Ning, Yan, Stintzing, Sebastian, Heinemann, Volker, Cao, Shu, Zhang, Wu, Yang, Dongyun, Miyamoto, Yuji, Suenaga, Mitsukuni, Schirripa, Marta, Hanna, Diana L., Soni, Shivani, Puccini, Alberto, Tokunaga, Ryuma, Naseem, Madiha, Battaglin, Francesca, Cremolini, Chiara, Falcone, Alfredo, Loupakis, Fotios, Lenz, Heinz-Josef
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513926/
https://ncbi.nlm.nih.gov/pubmed/32305727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2020.02.048
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