Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition

Mitogen-activated protein kinase (MAPK) pathway inhibitors show promise in treating melanoma, but are unsuccessful in achieving long-term remission. Concordant with clinical data, BRAF(V600E) melanoma cells eliminate glycolysis upon inhibition of BRAF(V600E) or MEK with the targeted therapies Vemura...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Serasinghe, Madhavika N., Gelles, Jesse D., Li, Kent, Zhao, Lauren, Abbate, Franco, Syku, Marie, Mohammed, Jarvier N., Badal, Brateil, Rangel, Cuahutlehuanitzin A., Hoehn, Kyle L., Celebi, Julide Tok, Chipuk, Jerry Edward
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833689/
https://ncbi.nlm.nih.gov/pubmed/29348439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0044-1
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