Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors

Mitochondrial division is essential for mitosis and metazoan development, but a mechanistic role in cancer biology remains unknown. Here, we examine the direct effects of oncogenic RAS(G12V) mediated cellular transformation on the mitochondrial dynamics machinery and observe a positive selection for...

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Udgivet i:Mol Cell
Main Authors: Serasinghe, Madhavika N., Weider, Shira Y., Renault, Thibaud T., Elkholi, Rana, Asciolla, James J., Yao, Jonathon L., Jabado, Omar, Hoehn, Kyle, Kageyama, Yusuke, Sesaki, Hiromi, Chipuk, Jerry E.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320323/
https://ncbi.nlm.nih.gov/pubmed/25658204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.003
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