Outer mitochondrial membrane shape engages BAX α9 to initiate mitochondrial outer membrane permeabilization and apoptosis

Pro-apoptotic BCL-2 proteins converge upon the outer mitochondrial membrane (OMM) to promote mitochondrial outer membrane permeabilization (MOMP) and apoptosis. Here we investigated the mechanistic relationship between mitochondrial shape and MOMP, and provide evidence that BAX requires a distinct m...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Renault, Thibaud T., Floros, Konstantinos V., Elkholi, Rana, Corrigan, Kelly-Ann, Kushnareva, Yulia, Wieder, Shira Y., Lindtner, Claudia, Serasinghe, Madhavika N., Asciolla, James J., Buettner, Christoph, Newmeyer, Donald D., Chipuk, Jerry E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289414/
https://ncbi.nlm.nih.gov/pubmed/25482509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.028
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