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Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition
Mitogen-activated protein kinase (MAPK) pathway inhibitors show promise in treating melanoma, but are unsuccessful in achieving long-term remission. Concordant with clinical data, BRAF(V600E) melanoma cells eliminate glycolysis upon inhibition of BRAF(V600E) or MEK with the targeted therapies Vemura...
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| Veröffentlicht in: | Cell Death Dis |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5833689/ https://ncbi.nlm.nih.gov/pubmed/29348439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0044-1 |
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