Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition

The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative phosphorylation. In melanoma arising from the V600E mutation in the kinase v-RAF murine sarcoma viral oncogene homolog B (BRAF(V600E)), oncogenic signaling...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Trotta, Andrew P., Gelles, Jesse D., Serasinghe, Madhavika N., Loi, Patrick, Arbiser, Jack L., Chipuk, Jerry E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2017
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512068/
https://ncbi.nlm.nih.gov/pubmed/28546431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786442
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