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Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition
The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative phosphorylation. In melanoma arising from the V600E mutation in the kinase v-RAF murine sarcoma viral oncogene homolog B (BRAF(V600E)), oncogenic signaling...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512068/ https://ncbi.nlm.nih.gov/pubmed/28546431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786442 |
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