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FBXW7 inactivation in a Braf(V600E)-driven mouse model leads to melanoma development
Human melanocytic nevi driven by BRAF(V600E) are in a growth-arrested state referred as oncogene-induced senescence. FBXW7 tumor suppressor is mutated in melanomas, but not in benign precursor melanocytic nevi. In order to characterize whether inactivation of FBXW7 in cooperation with BRAF(V600E) (B...
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Publicado no: | Pigment Cell Melanoma Res |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5668175/ https://ncbi.nlm.nih.gov/pubmed/28581198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12603 |
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