FBXW7 inactivation in a Braf(V600E)-driven mouse model leads to melanoma development

Human melanocytic nevi driven by BRAF(V600E) are in a growth-arrested state referred as oncogene-induced senescence. FBXW7 tumor suppressor is mutated in melanomas, but not in benign precursor melanocytic nevi. In order to characterize whether inactivation of FBXW7 in cooperation with BRAF(V600E) (B...

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Argitaratua izan da:Pigment Cell Melanoma Res
Egile Nagusiak: Aydin, Iraz T., Abbate, Franco, Rajan, Geena Susan, Badal, Brateil, Aifantis, Iannis, Desman, Garrett, Celebi, Julide Tok
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668175/
https://ncbi.nlm.nih.gov/pubmed/28581198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12603
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