Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis

Modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) comprise giant multidomain enzymes responsible for the “assembly line” biosynthesis of many genetically encoded small molecules. Site-directed mutagenesis, protein biochemical, and structural studies have focused on elu...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Trautman, Eric P., Healy, Alan R., Shine, Emilee E., Herzon, Seth B., Crawford, Jason M.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831107/
https://ncbi.nlm.nih.gov/pubmed/28240912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b00659
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