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Characterization of Natural Colibactin–Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening

Colibactins are genotoxic secondary metabolites whose biosynthesis is encoded in the clb gene cluster harbored by certain strains of gut commensal Escherichia coli. Using synthetic colibactin analogues, we previously provided evidence that colibactins alkylate DNA by addition of a nucleotide to an e...

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Publicado en:Biochemistry
Autores principales: Xue, Mengzhao, Shine, Emilee, Wang, Weiwei, Crawford, Jason M., Herzon, Seth B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997931/
https://ncbi.nlm.nih.gov/pubmed/30365310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01023
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