Loading...

Characterization of Natural Colibactin–Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening

Colibactins are genotoxic secondary metabolites whose biosynthesis is encoded in the clb gene cluster harbored by certain strains of gut commensal Escherichia coli. Using synthetic colibactin analogues, we previously provided evidence that colibactins alkylate DNA by addition of a nucleotide to an e...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Xue, Mengzhao, Shine, Emilee, Wang, Weiwei, Crawford, Jason M., Herzon, Seth B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997931/
https://ncbi.nlm.nih.gov/pubmed/30365310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01023
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!