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Depurination of colibactin-derived interstrand cross-links.
Colibactin is a genotoxic gut microbiome metabolite long suspected of playing an etiological role in colorectal cancer. Evidence suggests colibactin forms DNA interstrand cross-links (ICLs) in eukaryotic cells and activates ICL repair pathways, leading to the production of ICL-dependent DNA double-s...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7521609/ https://ncbi.nlm.nih.gov/pubmed/31977191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b01070 |
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