Wird geladen...

Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria

Colibactins are genotoxic secondary metabolites produced in select Enterobacteriaceae, which induce downstream DNA double-strand breaks (DSBs) in human cell lines and are thought to promote the formation of colorectal tumors. Although key structural and functional features of colibactins have been e...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Shine, Emilee E., Xue, Mengzhao, Patel, Jaymin R., Healy, Alan R., Surovtseva, Yulia V., Herzon, Seth B., Crawford, Jason M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001666/
https://ncbi.nlm.nih.gov/pubmed/30403848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00714
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!