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Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria
Colibactins are genotoxic secondary metabolites produced in select Enterobacteriaceae, which induce downstream DNA double-strand breaks (DSBs) in human cell lines and are thought to promote the formation of colorectal tumors. Although key structural and functional features of colibactins have been e...
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| 發表在: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001666/ https://ncbi.nlm.nih.gov/pubmed/30403848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00714 |
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