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Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria

Colibactins are genotoxic secondary metabolites produced in select Enterobacteriaceae, which induce downstream DNA double-strand breaks (DSBs) in human cell lines and are thought to promote the formation of colorectal tumors. Although key structural and functional features of colibactins have been e...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Biol
Prif Awduron: Shine, Emilee E., Xue, Mengzhao, Patel, Jaymin R., Healy, Alan R., Surovtseva, Yulia V., Herzon, Seth B., Crawford, Jason M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001666/
https://ncbi.nlm.nih.gov/pubmed/30403848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00714
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