LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity

BACKGROUND: LGR5 serves as a co-receptor for Wnt/β-catenin signalling and marks normal intestinal stem cells; however, its role in colorectal cancer (CRC) remains controversial. LGR5(+) cells are known to exist outside the stem cell niche during CRC progression, and the requirement for epidermal gro...

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Vydáno v:Br J Cancer
Hlavní autoři: Morgan, R G, Mortensson, E, Legge, D N, Gupta, B, Collard, T J, Greenhough, A, Williams, A C
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2018
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830587/
https://ncbi.nlm.nih.gov/pubmed/29149105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.412
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