LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE(2): implications for targeting adenoma stem cells with NSAIDs

Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E(2) (PGE(2)), promoting many hallmarks of cancer. Importantly, PGE(2) is reported to enhance Wnt/β-catenin signalling in colorectal carcinoma cells and in normal haematopoietic stem c...

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Detalhes bibliográficos
Main Authors: Al-Kharusi, Manal R.A., Smartt, Helena J.M., Greenhough, Alexander, Collard, Tracey J., Emery, Elizabeth D., Williams, Ann C., Paraskeva, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643418/
https://ncbi.nlm.nih.gov/pubmed/23349017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt020
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