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LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE(2): implications for targeting adenoma stem cells with NSAIDs
Cyclooxygenase-2 is overexpressed in the majority of colorectal tumours leading to elevated levels of prostaglandin E(2) (PGE(2)), promoting many hallmarks of cancer. Importantly, PGE(2) is reported to enhance Wnt/β-catenin signalling in colorectal carcinoma cells and in normal haematopoietic stem c...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Oxford University Press
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3643418/ https://ncbi.nlm.nih.gov/pubmed/23349017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt020 |
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