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Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic?
Leucine-rich repeat-containing G-protein coupled receptor (LGR5 or GPR49) potentiates canonical Wnt/β-catenin signalling and is a marker of normal stem cells in several tissues, including the intestine. Consistent with stem cell potential, single isolated LGR5(+) cells from the gut generate self-org...
Shranjeno v:
| izdano v: | Br J Cancer |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5988707/ https://ncbi.nlm.nih.gov/pubmed/29844449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0118-6 |
| Oznake: |
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