Structural properties and gene-silencing activity of chemically modified DNA–RNA hybrids with parallel orientation

We report, herein, a new class of RNAi trigger molecules based on the unconventional parallel hybridization of two oligonucleotide chains. We have prepared and studied several parallel stranded (ps) duplexes, in which the parallel orientation is achieved through incorporation of isoguanine and isocy...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Habibian, Maryam, Yahyaee-Anzahaee, Maryam, Lucic, Matije, Moroz, Elena, Martín-Pintado, Nerea, Di Giovanni, Logan Dante, Leroux, Jean-Christophe, Hall, Jonathan, González, Carlos, Damha, Masad J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Chemical Biology and Nucleic Acid Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829573/
https://ncbi.nlm.nih.gov/pubmed/29373740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky024
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