Structural properties and gene-silencing activity of chemically modified DNA–RNA hybrids with parallel orientation

We report, herein, a new class of RNAi trigger molecules based on the unconventional parallel hybridization of two oligonucleotide chains. We have prepared and studied several parallel stranded (ps) duplexes, in which the parallel orientation is achieved through incorporation of isoguanine and isocy...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Habibian, Maryam, Yahyaee-Anzahaee, Maryam, Lucic, Matije, Moroz, Elena, Martín-Pintado, Nerea, Di Giovanni, Logan Dante, Leroux, Jean-Christophe, Hall, Jonathan, González, Carlos, Damha, Masad J
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Chemical Biology and Nucleic Acid Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829573/
https://ncbi.nlm.nih.gov/pubmed/29373740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky024
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