Structural properties and gene-silencing activity of chemically modified DNA–RNA hybrids with parallel orientation

We report, herein, a new class of RNAi trigger molecules based on the unconventional parallel hybridization of two oligonucleotide chains. We have prepared and studied several parallel stranded (ps) duplexes, in which the parallel orientation is achieved through incorporation of isoguanine and isocy...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Habibian, Maryam, Yahyaee-Anzahaee, Maryam, Lucic, Matije, Moroz, Elena, Martín-Pintado, Nerea, Di Giovanni, Logan Dante, Leroux, Jean-Christophe, Hall, Jonathan, González, Carlos, Damha, Masad J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829573/
https://ncbi.nlm.nih.gov/pubmed/29373740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky024
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