Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes

OBJECTIVE: 20–50% of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain (LBD). While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our s...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Oncology
मुख्य लेखकों: Jia, Shanhang, Miedel, Mark T., Ngo, Marilyn, Hessenius, Ryan, Chen, Ning, Wang, Peilu, Bahreini, Amir, Li, Zheqi, Ding, Zhijie, Shun, Tong Ying, Zuckerman, Daniel M., Taylor, D. Lansing, Puhalla, Shannon L., Lee, Adrian V., Oesterreich, Steffi, Stern, Andrew M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828968/
https://ncbi.nlm.nih.gov/pubmed/29306943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000485510
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