Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes

OBJECTIVE: 20–50% of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain (LBD). While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our s...

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Bibliografiset tiedot
Julkaisussa:Oncology
Päätekijät: Jia, Shanhang, Miedel, Mark T., Ngo, Marilyn, Hessenius, Ryan, Chen, Ning, Wang, Peilu, Bahreini, Amir, Li, Zheqi, Ding, Zhijie, Shun, Tong Ying, Zuckerman, Daniel M., Taylor, D. Lansing, Puhalla, Shannon L., Lee, Adrian V., Oesterreich, Steffi, Stern, Andrew M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828968/
https://ncbi.nlm.nih.gov/pubmed/29306943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000485510
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