Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes

OBJECTIVE: 20–50% of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain (LBD). While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our s...

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保存先:
書誌詳細
出版年:Oncology
主要な著者: Jia, Shanhang, Miedel, Mark T., Ngo, Marilyn, Hessenius, Ryan, Chen, Ning, Wang, Peilu, Bahreini, Amir, Li, Zheqi, Ding, Zhijie, Shun, Tong Ying, Zuckerman, Daniel M., Taylor, D. Lansing, Puhalla, Shannon L., Lee, Adrian V., Oesterreich, Steffi, Stern, Andrew M.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828968/
https://ncbi.nlm.nih.gov/pubmed/29306943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000485510
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