Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes

OBJECTIVE: 20–50% of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain (LBD). While most studies focused on the constitutive ER signaling activity commonly engendered by these mutations selected during estrogen deprivation therapy, our s...

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Detalhes bibliográficos
Publicado no:Oncology
Main Authors: Jia, Shanhang, Miedel, Mark T., Ngo, Marilyn, Hessenius, Ryan, Chen, Ning, Wang, Peilu, Bahreini, Amir, Li, Zheqi, Ding, Zhijie, Shun, Tong Ying, Zuckerman, Daniel M., Taylor, D. Lansing, Puhalla, Shannon L., Lee, Adrian V., Oesterreich, Steffi, Stern, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828968/
https://ncbi.nlm.nih.gov/pubmed/29306943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000485510
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