A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function

Numerous posttranslational modifications have been described in kinesins, but their consequences on motor mechanics are largely unknown. We investigated one of these—acetylation of lysine 146 in Eg5—by creating an acetylation mimetic lysine to glutamine substitution (K146Q). Lysine 146 is located in...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: Muretta, Joseph M., Reddy, Babu J. N., Scarabelli, Guido, Thompson, Alex F., Jariwala, Shashank, Major, Jennifer, Venere, Monica, Rich, Jeremy N., Willard, Belinda, Thomas, David D., Stumpff, Jason, Grant, Barry J., Gross, Steven P., Rosenfeld, Steven S.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2018
Θέματα:
PNAS Plus
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828613/
https://ncbi.nlm.nih.gov/pubmed/29432173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718290115
Ετικέτες: Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

Παρόμοια τεκμήρια