A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function

Numerous posttranslational modifications have been described in kinesins, but their consequences on motor mechanics are largely unknown. We investigated one of these—acetylation of lysine 146 in Eg5—by creating an acetylation mimetic lysine to glutamine substitution (K146Q). Lysine 146 is located in...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Muretta, Joseph M., Reddy, Babu J. N., Scarabelli, Guido, Thompson, Alex F., Jariwala, Shashank, Major, Jennifer, Venere, Monica, Rich, Jeremy N., Willard, Belinda, Thomas, David D., Stumpff, Jason, Grant, Barry J., Gross, Steven P., Rosenfeld, Steven S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828613/
https://ncbi.nlm.nih.gov/pubmed/29432173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718290115
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