A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function

Numerous posttranslational modifications have been described in kinesins, but their consequences on motor mechanics are largely unknown. We investigated one of these—acetylation of lysine 146 in Eg5—by creating an acetylation mimetic lysine to glutamine substitution (K146Q). Lysine 146 is located in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Muretta, Joseph M., Reddy, Babu J. N., Scarabelli, Guido, Thompson, Alex F., Jariwala, Shashank, Major, Jennifer, Venere, Monica, Rich, Jeremy N., Willard, Belinda, Thomas, David D., Stumpff, Jason, Grant, Barry J., Gross, Steven P., Rosenfeld, Steven S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828613/
https://ncbi.nlm.nih.gov/pubmed/29432173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718290115
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados