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The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5

Kinesins perform mechanical work to power a variety of cellular functions, from mitosis to organelle transport. Distinct functions shape distinct enzymologies, and this is illustrated by comparing kinesin-1, a highly processive transport motor that can work alone, to Eg5, a minimally processive mito...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Muretta, Joseph M., Jun, Yonggun, Gross, Steven P., Major, Jennifer, Thomas, David D., Rosenfeld, Steven S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672802/
https://ncbi.nlm.nih.gov/pubmed/26627252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512305112
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