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The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5
Kinesins perform mechanical work to power a variety of cellular functions, from mitosis to organelle transport. Distinct functions shape distinct enzymologies, and this is illustrated by comparing kinesin-1, a highly processive transport motor that can work alone, to Eg5, a minimally processive mito...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4672802/ https://ncbi.nlm.nih.gov/pubmed/26627252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512305112 |
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