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The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5
Kinesins perform mechanical work to power a variety of cellular functions, from mitosis to organelle transport. Distinct functions shape distinct enzymologies, and this is illustrated by comparing kinesin-1, a highly processive transport motor that can work alone, to Eg5, a minimally processive mito...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4672802/ https://ncbi.nlm.nih.gov/pubmed/26627252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512305112 |
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