A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function

Numerous posttranslational modifications have been described in kinesins, but their consequences on motor mechanics are largely unknown. We investigated one of these—acetylation of lysine 146 in Eg5—by creating an acetylation mimetic lysine to glutamine substitution (K146Q). Lysine 146 is located in...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Muretta, Joseph M., Reddy, Babu J. N., Scarabelli, Guido, Thompson, Alex F., Jariwala, Shashank, Major, Jennifer, Venere, Monica, Rich, Jeremy N., Willard, Belinda, Thomas, David D., Stumpff, Jason, Grant, Barry J., Gross, Steven P., Rosenfeld, Steven S.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2018
נושאים:
PNAS Plus
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828613/
https://ncbi.nlm.nih.gov/pubmed/29432173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718290115
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