Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction – implications for treating preeclampsia

INTRODUCTION: The discovery of new treatments that prevent or treat preeclampsia would be a major advance. Antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are secreted in excess from the placenta, causing hypertension, endothelial dysfunction, and multi...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kaitu’u-Lino, Tu’uhevaha J., Brownfoot, Fiona C., Beard, Sally, Cannon, Ping, Hastie, Roxanne, Nguyen, Tuong V., Binder, Natalie K., Tong, Stephen, Hannan, Natalie J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821305/
https://ncbi.nlm.nih.gov/pubmed/29466360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188845
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