Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

BACKGROUND: Preeclampsia is associated with the placental release of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG). These anti-angiogenic factors cause hypertension and multi-organ injury. Pravastatin decreases placental secretion of sFlt-1 in vitro and is currently being e...

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Détails bibliographiques
Publié dans:BMC Pregnancy Childbirth
Auteurs principaux: Brownfoot, Fiona C., Tong, Stephen, Hannan, Natalie J., Hastie, Roxanne, Cannon, Ping, Kaitu’u-Lino, Tu’uhevaha J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874016/
https://ncbi.nlm.nih.gov/pubmed/27207105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12884-016-0902-3
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