Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

BACKGROUND: Preeclampsia is a major complication of pregnancy with no medical treatment. It is associated with placental oxidative stress, hypoxia and inflammation leading to soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion and reduced placental growth factor (PlGF)....

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Brownfoot, Fiona C., Hannan, Natalie J., Cannon, Ping, Nguyen, Vi, Hastie, Roxanne, Parry, Laura J., Senadheera, Sevvandi, Tuohey, Laura, Tong, Stephen, Kaitu'u-Lino, Tu'uhevaha J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442229/
https://ncbi.nlm.nih.gov/pubmed/30824385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.02.013
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