Dacomitinib potentiates the efficacy of conventional chemotherapeutic agents via inhibiting the drug efflux function of ABCG2 in vitro and in vivo

BACKGROUND: ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and decreasing their intracellular accumulation. MDR is a major hurdle to successful...

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Pubblicato in:J Exp Clin Cancer Res
Autori principali: Guo, Xiaoran, To, Kenneth K. W., Chen, Zhen, Wang, Xiaokun, Zhang, Jianye, Luo, Min, Wang, Fang, Yan, Shirong, Fu, Liwu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819299/
https://ncbi.nlm.nih.gov/pubmed/29458405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0690-x
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