Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo

Multidrug resistance (MDR) is the leading cause of treatment failure in cancer chemotherapy. The overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, ABCC1 and ABCG2, play a key role in mediating MDR by pumping anticancer drugs out from cancer cells. Ceritinib (LDK378) is a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hu, Jing, Zhang, Xu, Wang, Fang, Wang, Xiaokun, Yang, Ke, Xu, Meng, To, Kenneth K.W., Li, Qingshan, Fu, Liwu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792582/
https://ncbi.nlm.nih.gov/pubmed/26556876
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