Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo

Multidrug resistance (MDR) is the leading cause of treatment failure in cancer chemotherapy. The overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, ABCC1 and ABCG2, play a key role in mediating MDR by pumping anticancer drugs out from cancer cells. Ceritinib (LDK378) is a...

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Vydáno v:Oncotarget
Hlavní autoři: Hu, Jing, Zhang, Xu, Wang, Fang, Wang, Xiaokun, Yang, Ke, Xu, Meng, To, Kenneth K.W., Li, Qingshan, Fu, Liwu
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792582/
https://ncbi.nlm.nih.gov/pubmed/26556876
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