Rociletinib (CO-1686) enhanced the efficacy of chemotherapeutic agents in ABCG2-overexpressing cancer cells in vitro and in vivo

Overexpression of adenosine triphosphate (ATP)-binding cassette subfamily G member 2 (ABCG2) in cancer cells is known to cause multidrug resistance (MDR), which severely limits the clinical efficacy of chemotherapy. Currently, there is no FDA-approved MDR modulator for clinical use. In this study, r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Pharm Sin B
Main Authors: Zeng, Fanpu, Wang, Fang, Zheng, Zongheng, Chen, Zhen, Wah To, Kenneth Kin, Zhang, Hong, Han, Qian, Fu, Liwu
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
Teme:
Original article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7280144/
https://ncbi.nlm.nih.gov/pubmed/32528828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.01.008
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