CM082 Enhances the Efficacy of Chemotherapeutic Drugs by Inhibiting the Drug Efflux Function of ABCG2

The overexpression of ATP-binding cassette (ABC) transporters is one of the important mechanisms of multidrug resistance (MDR). Some tyrosine kinase inhibitors (TKIs) such as CM082 might be a potential ABC transporter inhibitor, thus potentially reversing MDR. We used a 3-(4,5-dimethylthiazol-2-yl)-...

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Publicado no:Mol Ther Oncolytics
Main Authors: Xu, Lejia, Huang, Jiwei, Liu, Jie, Xi, Yun, Zheng, Zongheng, To, Kenneth K.W., Chen, Zhen, Wang, Fang, Zhang, Yongming, Fu, Liwu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005336/
https://ncbi.nlm.nih.gov/pubmed/32055675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.12.007
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