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Conformational Heterogeneity and the Affinity of Substrate Molecular Recognition by Cytochrome P450cam

The broad and variable substrate specificity of cytochrome P450 enzymes makes them a model system for studying the determinants of protein molecular recognition. The archetypal cytochrome P450cam (P450cam) is a relatively specific P450, a feature once attributed to the high rigidity of its active si...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biochemistry
Hauptverfasser: Basom, Edward J., Manifold, Bryce A., Thielges, Megan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816979/
https://ncbi.nlm.nih.gov/pubmed/28581729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00238
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