Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC progenitors during embryogenesis before Shh production by Purkinje neurons and their roles in tumorigenesis remain unclear. The cilium-localized...

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Udgivet i:Cell Rep
Main Authors: Shimada, Issei S., Hwang, Sun-Hee, Somatilaka, Bandarigoda N., Wang, Xin, Skowron, Patryk, Kim, Jiwoong, Kim, Min, Shelton, John M., Rajaram, Veena, Xuan, Zhenyu, Taylor, Michael D., Mukhopadhyay, Saikat
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813698/
https://ncbi.nlm.nih.gov/pubmed/29386106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.018
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