Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC progenitors during embryogenesis before Shh production by Purkinje neurons and their roles in tumorigenesis remain unclear. The cilium-localized...

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Dades bibliogràfiques
Publicat a:Cell Rep
Autors principals: Shimada, Issei S., Hwang, Sun-Hee, Somatilaka, Bandarigoda N., Wang, Xin, Skowron, Patryk, Kim, Jiwoong, Kim, Min, Shelton, John M., Rajaram, Veena, Xuan, Zhenyu, Taylor, Michael D., Mukhopadhyay, Saikat
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813698/
https://ncbi.nlm.nih.gov/pubmed/29386106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.018
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