Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC progenitors during embryogenesis before Shh production by Purkinje neurons and their roles in tumorigenesis remain unclear. The cilium-localized...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Shimada, Issei S., Hwang, Sun-Hee, Somatilaka, Bandarigoda N., Wang, Xin, Skowron, Patryk, Kim, Jiwoong, Kim, Min, Shelton, John M., Rajaram, Veena, Xuan, Zhenyu, Taylor, Michael D., Mukhopadhyay, Saikat
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813698/
https://ncbi.nlm.nih.gov/pubmed/29386106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.018
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