Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status

The multistep process of TP53 mutation expansion during myeloproliferative neoplasm (MPN) transformation into acute myeloid leukemia (AML) has been documented retrospectively. It is currently unknown how common TP53 mutations with low variant allele frequency (VAF) are, whether they are linked to hy...

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Dettagli Bibliografici
Pubblicato in:Leukemia
Autori principali: Kubesova, B, Pavlova, S, Malcikova, J, Kabathova, J, Radova, L, Tom, N, Tichy, B, Plevova, K, Kantorova, B, Fiedorova, K, Slavikova, M, Bystry, V, Kissova, J, Gisslinger, B, Gisslinger, H, Penka, M, Mayer, J, Kralovics, R, Pospisilova, S, Doubek, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808067/
https://ncbi.nlm.nih.gov/pubmed/28744014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.230
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