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Bioinformatic pipelines for whole transcriptome sequencing data exploitation in leukemia patients with complex structural variants

BACKGROUND: Extensive genome rearrangements, known as chromothripsis, have been recently identified in several cancer types. Chromothripsis leads to complex structural variants (cSVs) causing aberrant gene expression and the formation of de novo fusion genes, which can trigger cancer development, or...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Hynst, Jakub, Plevova, Karla, Radova, Lenka, Bystry, Vojtech, Pal, Karol, Pospisilova, Sarka
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571010/
https://ncbi.nlm.nih.gov/pubmed/31223530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.7071
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