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Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones

In chronic lymphocytic leukemia, usually a monoclonal disease, multiple productive immunoglobulin heavy chain gene rearrangements are identified sporadically. Prognostication of such cases based on immunoglobulin heavy variable gene mutational status can be problematic, especially if the different r...

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Detalhes bibliográficos
Main Authors: Plevova, Karla, Francova, Hana Skuhrova, Burckova, Katerina, Brychtova, Yvona, Doubek, Michael, Pavlova, Sarka, Malcikova, Jitka, Mayer, Jiri, Tichy, Boris, Pospisilova, Sarka
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912964/
https://ncbi.nlm.nih.gov/pubmed/24038023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.087593
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