ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

ATM abnormalities are frequent in chronic lymphocytic leukemia and represent an important prognostic factor. Sole 11q deletion does not result in ATM inactivation by contrast to biallelic defects involving mutations. Therefore, the analysis of ATM mutations and their functional impact is crucial. In...

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Bibliografische gegevens
Hoofdauteurs: Navrkalova, Veronika, Sebejova, Ludmila, Zemanova, Jana, Kminkova, Jana, Kubesova, Blanka, Malcikova, Jitka, Mraz, Marek, Smardova, Jana, Pavlova, Sarka, Doubek, Michael, Brychtova, Yvona, Potesil, David, Nemethova, Veronika, Mayer, Jiri, Pospisilova, Sarka, Trbusek, Martin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ferrata Storti Foundation 2013
Onderwerpen:
Original Articles and Brief Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696617/
https://ncbi.nlm.nih.gov/pubmed/23585524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.081620
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