ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

ATM abnormalities are frequent in chronic lymphocytic leukemia and represent an important prognostic factor. Sole 11q deletion does not result in ATM inactivation by contrast to biallelic defects involving mutations. Therefore, the analysis of ATM mutations and their functional impact is crucial. In...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Navrkalova, Veronika, Sebejova, Ludmila, Zemanova, Jana, Kminkova, Jana, Kubesova, Blanka, Malcikova, Jitka, Mraz, Marek, Smardova, Jana, Pavlova, Sarka, Doubek, Michael, Brychtova, Yvona, Potesil, David, Nemethova, Veronika, Mayer, Jiri, Pospisilova, Sarka, Trbusek, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2013
Soggetti:
Original Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696617/
https://ncbi.nlm.nih.gov/pubmed/23585524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.081620
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi