Autocrine signaling by Wnt-5a deregulates chemotaxis of leukemic cells and predicts clinical outcome in chronic lymphocytic leukemia

BACKGROUND: ROR1, a receptor in the non-canonical Wnt/planar cell polarity (PCP) pathway, is up-regulated in malignant B cells of chronic lymphocytic leukemia (CLL) patients. It has been shown that Wnt/PCP pathway drives pathogenesis of CLL, but which factors activate ROR1 and PCP pathway in CLL cel...

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Publicat a:Clin Cancer Res
Autors principals: Janovska, Pavlina, Poppova, Lucie, Plevova, Karla, Plesingerova, Hana, Behal, Martin, Kaucka, Marketa, Ovesna, Petra, Hlozkova, Michaela, Borsky, Marek, Stehlikova, Olga, Brychtova, Yvona, Doubek, Michael, Machalova, Michaela, Baskar, Sivasubramanian, Kozubik, Alois, Pospisilova, Sarka, Pavlova, Sarka, Bryja, Vitezslav
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716000/
https://ncbi.nlm.nih.gov/pubmed/26240275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0154
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