Whole-exome sequencing identifies novel MPL and JAK2 mutations in triple-negative myeloproliferative neoplasms

Essential thrombocythemia (ET) and primary myelofibrosis (PMF) are chronic diseases characterized by clonal hematopoiesis and hyperproliferation of terminally differentiated myeloid cells. The disease is driven by somatic mutations in exon 9 of CALR or exon 10 of MPL or JAK2-V617F in >90% of the...

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Pubblicato in:Blood
Autori principali: Milosevic Feenstra, Jelena D., Nivarthi, Harini, Gisslinger, Heinz, Leroy, Emilie, Rumi, Elisa, Chachoua, Ilyas, Bagienski, Klaudia, Kubesova, Blanka, Pietra, Daniela, Gisslinger, Bettina, Milanesi, Chiara, Jäger, Roland, Chen, Doris, Berg, Tiina, Schalling, Martin, Schuster, Michael, Bock, Christoph, Constantinescu, Stefan N., Cazzola, Mario, Kralovics, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752213/
https://ncbi.nlm.nih.gov/pubmed/26423830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-07-661835
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