Two-Step Macrocycle Synthesis by Classical Ugi Reaction

[Image: see text] The direct nonpeptidic macrocycle synthesis of α-isocyano-ω-amines via the classical Ugi four-component reaction (U-4CR) is introduced. Herein an efficient and flexible two-step procedure to complex macrocycles is reported. In the first step, the reaction between unprotected diamin...

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Bibliografske podrobnosti
izdano v:J Org Chem
Main Authors: Abdelraheem, Eman M. M., Khaksar, Samad, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Shaabani, Shabnam, Dömling, Alexander
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799868/
https://ncbi.nlm.nih.gov/pubmed/29327924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b02984
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