Two-Step Synthesis of Complex Artificial Macrocyclic Compounds

The design and synthesis of head-to-tail linked artificial macrocycles using the Ugi-reaction has been developed. This synthetic approach of just two steps is unprecedented, short, efficient and works over a wide range of medium (8–11) and macrocyclic (≥12) loop sizes. The substrate scope and functi...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Madhavachary, Rudrakshula, Abdelraheem, Eman M. M., Rossetti, Arianna, Twarda-Clapa, Aleksandra, Musielak, Bogdan, Katarzyna, Kurpiewska, Justyna, Kalinowska-Tłuścik, Holak, Tad A., Dömling, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660312/
https://ncbi.nlm.nih.gov/pubmed/28691783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201704426
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