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Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction

[Image: see text] Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Comb Sci
Prif Awduron: Patil, Pravin, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Dömling, Alexander
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2017
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424440/
https://ncbi.nlm.nih.gov/pubmed/28240545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.7b00033
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