A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses

The entorhinal cortex (EC) is one of the most vulnerable brain regions that is attacked during the early stage of Alzheimer’s disease (AD). Here, we report that the synaptic terminals of pyramidal neurons in the EC layer II (ECII(PN)) directly innervate CA1 parvalbumin (PV) neurons (CA1(PV)) and are...

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Bibliografiske detaljer
Udgivet i:Mol Psychiatry
Main Authors: Yang, X, Yao, C, Tian, T, Li, X, Yan, H, Wu, J, Li, H, Pei, L, Liu, D, Tian, Q, Zhu, L-Q, Lu, Y
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2018
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794875/
https://ncbi.nlm.nih.gov/pubmed/27671476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.151
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